DRUG  RASH

Etiology:     

1. Common drugs (PCN, erythro, sulfa). One  must consider  mononucleosis (EBV) if rash develops when  taking  ampicillin,  or HIV if one develops rash on  sulfa.

S & S / DX:

1. One can develop Early  reaction (2-3 days after exposure) if previously sensitized or  Late reaction  (1-3 wk. after exposure).
    
2. It is present mainly on chest,  trunk, UE and LE. Palms and soles affected in 50%. Rash usually morbilliform (macules and papules). Pruritus and fever may be present.

1. Antihistamines
           
2. Discontinue offending agents
    
3. Topical steroids for pruritis.

FIXED  DRUG  REACTION

Etiology:

1. Barbiturates, phenolphthalein (found in laxatives),

1. Usually solitary. Genitalia is the most common site.
    
2. May be pruritic, dark red to brown in color  with irregular margins.
    
3. May be recurrent and always presents at the same site as previous lesion.
    
4. Appears within hours of  taking the drug.
    
5. May persist for months.

1. Supportive.

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